J. Douglas Armstrong & Wayne Davies

BRAINWAVE, J. Douglas Armstrong and Wayne Davies

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Scientific Expertise & Collaborations

Brainwave-Discovery Ltd (BWD) is a spin-out company from the Universities of Edinburgh and Glasgow. BWD provides contract research services to CNS drug discovery teams in the pharmaceutical and biotechnology sectors. It specialises in the generation and analysis of humanised transgenic Drosophila as molecular pathway models for a range of CNS disorders. Patent protected assays allow rapid pharmacology, anatomy and behavioural phenotyping of new strains. BWD is currently working on over 50 human disease genes (linked to a range of cognitive and neurological disorders). BWD is a full commercial partner in the SynSYS (HEALTH-F4-2010-242167) consortium building a range of Drosophila models for human disease genes with 11 European partners.

Training Expertise

Both the CEO (Wayne Davies) and CSO (Douglas Armstrong) have appointments at the University of Edinburgh and are active in postgraduate training with over 20 graduates between them, several now in established senior academic or industrial positions. The company is closely affiliated with both founding universities and rents incubator premises within the University of Edinburgh, which also hosts the UK doctoral training programme in Neuro-informatics with which BWD is affiliated. BWD is also affiliated with Informatics-Ventures, which provide entrepreneurship training and mentoring for new high-tech technology ventures and research groups.

Training & Research Environment

As a spin-out physically located within a university and working closely in collaboration with research groups in both academia and in the pharmaceutical industry means we can leverage both environments to provide insights into translational research. Although primarily focussed on contract research activities, BWD also interacts closely with the business development arms of pharmaceutical companies as well as strategic leaders in the replacement and refinement of animal models in the drug discovery sector.

Most relevant publications/patents

1.Wessnitzer J, Young JM, Armstrong JD, Webb B (2011) A model of non-elemental olfactory learning in DrosophilaJ Comput Neurosci. 2011 Jun 23

2. Krashes MJ, DasGupta S, Vreede A, White B, Armstrong J.D., Waddell S (2009). A neural circuit mechanism integrating motivational state with memory expression in Drosophila. Cell 16;139(2):416-27.

3. SGN Grant, MC Marshall, K-L Page, MA Cumiskey, Armstrong J.D. (2005). Systematic curation of human mutations and diseases in NMDA receptor multiprotein complex genes. Human Molecular Genetics 14: R225-34

4. Kaiser K, Rosay P and Armstrong J.D. (1999). Detection of neural activity; UK patent application GB9812127.0 (1998) International patent application PCT/GB99/01786. Granted US, EU, pending Japan