What makes Drosophila different? A complete database to give the answer

"The Drosophila Genetic Reference Panel, or DGRP, includes genome sequences, population genomic data, and other data for almost 200Drosophila melanogaster lines. The result is a community resource that North Carolina State University geneticist Trudy Mackay, co-first author on the Nature study, called a "living library of genetic variation " - genomeweb article

Author's abstract: 

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype–phenotype map were based on incomplete genotypic information. Here, we describe theDrosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype–phenotype mapping using the power of Drosophila genetics

Press Coverage:

http://www.genomeweb.com/node/1027101

http://www.ncbi.nlm.nih.gov/pubmed/22318601

http://www.nature.com/nature/journal/v482/n7384/full/nature10811.html