Ilona Grunwald Kadow

Ilona Grunwald Kadow

MPIN, Ilona Grunwald Kadow (IK)

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Scientific Expertise & Collaborations:  The interest of the Kadow lab is the formation, function and evolutionary divergence of sensory systems in insects with a main focus on the CO2 sensory system. Techniques used are genetics, microscopy, behaviour analysis, and in vivo functional imaging and electrophysiology. In addition to the main model organism Drosophila, the lab recently started to work on mosquitoes. Three main research directions are currently being followed in the lab: (i) Molecular mechanisms of olfactory system development and divergence, (ii) functional mapping of neural circuits underpinning innate olfactory behaviour, and (iii) context dependent modification of innate behaviour. The lab collaborates with several groups in- and outside Europe.

Training Expertise: IK supervises 6 graduate students, 2 postdocs and 2 technicians. The lab hosted 5 summer students. IK is a member of the IMPRS graduate school, the graduate school of Neurosciences (GSN, Munich), and teaches regularly at the Ludwig Maximilian University in Munich.

Training & Research Environment: The Max Planck Institute of Neurobiology (MPIN) is an international institute in neurosciences with combined expertise in developmental and molecular neurobiology, systems neuroscience, behavioural neurosciences, genetics, imaging techniques and development of Ca2+-indicators using different model organisms. The institute collaborates with the Universities of Munich and the Bernstein centre for computational neurosciences. The institute has state-of-the-art facilities: sequencing, protein/biochemistry service, quantitative mass spec and proteomics, microscopy and imaging, mouse house, histology and electron microscopy.

The MPIN participates in a number of graduate programmes including the International Max Planck Research School for Molecular and Cellular Life Sciences (IMPRS, http://www.imprs-mcbb.de/). Regular scientific seminars by institute members and international speakers at the institute and surrounding institutes secure continuous training in a broad area of scientific topics.

The MPIN offers a list of soft skill and language training courses. The press office of the institute organises a yearly ‘open door’ day for the public and a monthly lecture series on ‘Science talks for the general public’.

Most relevant publications:

1. Hartl, M., L.F. Loschek, D. Stephan, K.P. Siju, C. Knappmeyer, and I.C. Grunwald Kadow (2011) A New Prospero and microRNA-279 Pathway Restricts CO2 Receptor Neuron Formation. J Neurosci. 31 (44)

2. Cayirlioglu, P.*, Grunwald Kadow, I.*, Zhan, X., Okamura, K., Gunning, D., Lai, E.C., and Zipursky, S.L. (2008). Hybrid Neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science 319, 1256-1260 (*=equal contribution)

3. Jones, W. D., Cayirlioglu, P., Grunwald Kadow, I. and Vosshall, L.B. (2007). Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature 445, 86-90.